Herpes zoster ophthalmicus and the risk of stroke: A population-based follow-up study

Herng Ching Lin, Ching Wen Chien, Jau Der Ho

研究成果: 雜誌貢獻文章

107 引文 (Scopus)

摘要

Objective: To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO). METHODS: Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors. Results: Stroke developed in 8.1% of patients with HZO and 1.7% of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95% confidence interval 2.45-8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not. Conclusions: Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.

原文英語
頁(從 - 到)792-797
頁數6
期刊Neurology
74
發行號10
DOIs
出版狀態已發佈 - 三月 2010

指紋

Herpes Zoster Ophthalmicus
Stroke
Population
Survival Rate
National Health Programs
International Classification of Diseases
Taiwan
Habits
Antiviral Agents
Comorbidity

ASJC Scopus subject areas

  • Clinical Neurology

引用此文

Herpes zoster ophthalmicus and the risk of stroke : A population-based follow-up study. / Lin, Herng Ching; Chien, Ching Wen; Ho, Jau Der.

於: Neurology, 卷 74, 編號 10, 03.2010, p. 792-797.

研究成果: 雜誌貢獻文章

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abstract = "Objective: To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO). METHODS: Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors. Results: Stroke developed in 8.1{\%} of patients with HZO and 1.7{\%} of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95{\%} confidence interval 2.45-8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not. Conclusions: Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.",
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N2 - Objective: To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO). METHODS: Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors. Results: Stroke developed in 8.1% of patients with HZO and 1.7% of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95% confidence interval 2.45-8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not. Conclusions: Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.

AB - Objective: To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO). METHODS: Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors. Results: Stroke developed in 8.1% of patients with HZO and 1.7% of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95% confidence interval 2.45-8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not. Conclusions: Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.

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