摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 391-398 |
| 頁數 | 8 |
| 期刊 | Phytotherapy Research |
| 卷 | 8 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | 已發佈 - 1994 |
指紋
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
引用此文
Hepatoprotective effects of Taiwan folk medicine : Alternanthera sessilis on liver damage induced by various hepatotoxins. / Lin, Song-Chow; Lin, Y.; Shyuu, S.; Lin, C.
於: Phytotherapy Research, 卷 8, 編號 7, 1994, p. 391-398.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Hepatoprotective effects of Taiwan folk medicine
T2 - Alternanthera sessilis on liver damage induced by various hepatotoxins
AU - Lin, Song-Chow
AU - Lin, Y.
AU - Shyuu, S.
AU - Lin, C.
PY - 1994
Y1 - 1994
N2 - The hepatoprotective effects of the Taiwanese herb 'Horngtyan-wu' (Alternanthera sessilis (L.) DC.) were investigated in three kinds of experimental animal model. Acute hepatitis was induced by various chemicals such as carbon tetrachloride (31.25 μL/kg, i.p.) or acetaminophen (paracetamol; 600 mg/kg, i.p.) in mice and D(+)-galactosamine (188 mg/kg, i.p.) in rats. When treated with A. sessilis (300 mg/kg, p.o.) at 2, 6 and 10 h, a reduction in elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels could be observed at 24 h after administration of the three hepatotoxins. These serological observations were also confirmed by histopathological examinations including centrilobular necrosis, eosinophilic bodies, pyknotic nuclei, microvesicular degeneration of hepatocytes and others. The liver microscopic examination showed a noted improvement in groups receiving A. sessilis. All pharmacological and histopathological effects were compared with observations using the hepatoprotective Chinese herb, Bupleurum chinense (Family Umbelliferae). It was confirmed that A. sessilis has hepatoprotective effects against liver injuries induced by hepatotoxins with different mechanisms.
AB - The hepatoprotective effects of the Taiwanese herb 'Horngtyan-wu' (Alternanthera sessilis (L.) DC.) were investigated in three kinds of experimental animal model. Acute hepatitis was induced by various chemicals such as carbon tetrachloride (31.25 μL/kg, i.p.) or acetaminophen (paracetamol; 600 mg/kg, i.p.) in mice and D(+)-galactosamine (188 mg/kg, i.p.) in rats. When treated with A. sessilis (300 mg/kg, p.o.) at 2, 6 and 10 h, a reduction in elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels could be observed at 24 h after administration of the three hepatotoxins. These serological observations were also confirmed by histopathological examinations including centrilobular necrosis, eosinophilic bodies, pyknotic nuclei, microvesicular degeneration of hepatocytes and others. The liver microscopic examination showed a noted improvement in groups receiving A. sessilis. All pharmacological and histopathological effects were compared with observations using the hepatoprotective Chinese herb, Bupleurum chinense (Family Umbelliferae). It was confirmed that A. sessilis has hepatoprotective effects against liver injuries induced by hepatotoxins with different mechanisms.
KW - acetaminophen
KW - Alternanthera sissilis
KW - Bupleurum chinense
KW - carb on tetrachloride
KW - galactosamine
KW - hepatoprotective
KW - paracetamol
UR - http://www.scopus.com/inward/record.url?scp=0028091797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028091797&partnerID=8YFLogxK
U2 - 10.1002/ptr.2650080703
DO - 10.1002/ptr.2650080703
M3 - Article
AN - SCOPUS:0028091797
VL - 8
SP - 391
EP - 398
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 7
ER -