Hepatoprotective effect of the aqueous extract of flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities

Po Chow Hsieh, Yu Ling Ho, Guan Jhong Huang, Ming Hsing Huang, Ying Chen Chiang, Shyh Shyun Huang, Wen Chi Hou, Yuan Shiun Chang

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

This study investigated the protective effect of the aqueous extract of Flemingia macrophylla (AFM) against hepatic injury induced by CCl4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarkers in the blood to indicate hepatic injury. Product of lipid peroxidation (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed for the degree of hepatic injury. After oral administration of AFM, 0.5 g/kg and 1.0 g/kg doses significantly decreased ALT and AST, attenuated the histopathology of hepatic injury, ameliorated oxidative stress in hepatic tissue, and increased the activities of CAT, SOD and GSH-Px. The hepatoprotective effect of daidzein and genistein were consistent to that of AFM. This study demonstrated for the first time that AFM has hepatoprotective effect on acute liver injuries induced by CCl4, and the results suggested that the effect of AFM against CCl4-induced liver damage was related to antioxidant properties.

原文英語
頁(從 - 到)349-365
頁數17
期刊American Journal of Chinese Medicine
39
發行號2
DOIs
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • 補充和替代醫學

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