Hepatoprotective activity of Taiwan folk medicine: Eclipta prostrata Linn. against various hepatotoxins induced acute hepatotoxicity

Song-Chow Lin, Chih Jung Yao, Chun Ching Lin, Yun Ho Lin

研究成果: 雜誌貢獻文章

29 引文 斯高帕斯(Scopus)

摘要

The hepatoprotective effects of Eclipta prostrata (Linn.) were studied on acute hepatitis induced in mice by a single dose of carbon tetrachloride (31.25 μL/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) and in rats by a single dose of β-D-galactosamine (188 mg/kg, i.p.). the hepatoprotective activity was monitored by estimating the serum transaminases (SGOT and SGPT) levels and histopathological changes in the liver of experimental animals. The Eclipta prostrata extracts significantly inhibited the acute elevation of serum transaminases induced by carbon tetrachloride in mice and by β-D-GaLN in rats. However, in the experimental model of acetaminophen, although an inhibiting tendency was noticed, no statistical significance was observed. Histopathologically, the crude E. prostrata extract significantly ameliorates either CCl4 or GaLN-induced histopathological changes in the liver of experimental animals but no statistically significant improvement could be observed in acetaminophen induced liver damage. All serological and histopathological effects of Eclipta prostrata were compared with that of Bupleurum chinense DC., which has been previously reported and used as a treatment criteria for hepatitis (Chiu et al., 1988; 1989; Lin et al., 1990a, b).
原文英語
頁(從 - 到)483-490
頁數8
期刊Phytotherapy Research
10
發行號6
DOIs
出版狀態已發佈 - 1996

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

指紋 深入研究「Hepatoprotective activity of Taiwan folk medicine: Eclipta prostrata Linn. against various hepatotoxins induced acute hepatotoxicity」主題。共同形成了獨特的指紋。

  • 引用此