Hepatitis C Virus Reinfection in People With HIV in Taiwan After Achieving Sustained Virologic Response With Antiviral Treatment: The RECUR Study

Chen Hua Liu, Hsin Yun Sun, Cheng Yuan Peng, Szu Min Hsieh, Sheng Shun Yang, Wei Yu Kao, Yu Lueng Shih, Chih Lin Lin, Chun Jen Liu, Wang Hui Sheng, Yi Chun Lo, Wen Chun Liu, Jo Hsuan Wu, Tung Hung Su, Tai Chung Tseng, Pei Jer Chen, Chien Ching Hung, Jia Horng Kao

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Data on hepatitis C virus (HCV) reinfection in East Asian people with HIV after treatment-induced sustained virologic response (SVR) are limited. Methods: HIV/HCV-coinfected patients in Taiwan who achieved SVR12 with interferon (IFN) or direct-acting antivirals (DAAs) between 2005 and 2021 underwent HCV RNA measurements at SVR24 and then biannually. HCV reinfection was defined as the detection of different HCV strains beyond SVR12. HIV-negative, low-risk individuals with SVR12 served as reference patients. Crude reinfection rates and secular trends were assessed. Multivariate Cox regression analysis was performed to identify baseline factors associated with HCV reinfection. Results: A total of 216 HIV-positive and 1589 reference patients were recruited, with median follow-up durations of 3.0 and 6.0 years, respectively. During a total of 772 person-years of follow-up (PYFU), the HCV reinfection rate in HIV-positive patients was 4.02 per 100 PYFU (95% CI, 2.85-5.65), while the HCV reinfection rate in reference patients was 0.14 per 100 PYFU (95% CI, 0.09-0.23) during 10 862 PYFU. HIV-positive patients had a higher risk of HCV reinfection than reference patients (hazard ratio [HR], 17.63; 95% CI, 7.10-43.80; P
原文英語
文章編號ofac348
期刊Open Forum Infectious Diseases
9
發行號8
DOIs
出版狀態已發佈 - 8月 1 2022

ASJC Scopus subject areas

  • 腫瘤科
  • 傳染性疾病

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