Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Su, F-H., Chang, S. N., Sung, F. C., Su, C-T., Shieh, Y-H., Lin, C. C., & Yeh, C-C. (2014). Hepatitis B virus infection and the risk of male infertility: A population-based analysis. Fertility and Sterility, 102(6), 1677-1684. https://doi.org/10.1016/j.fertnstert.2014.09.017