Heatstroke effect on brain heme oxygenase-1 in rats

Ya Ting Wen, Tsung Ta Liu, Yuh Feng Lin, Chun Chi Chen, Woon Man Kung, Chi Chang Huang, Tien Jen Lin, Yuan Hung Wang, Li Wei

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

Exposure to high environmental temperature leading to increased core body temperature above 40°C and central nervous system abnormalities such as convulsions, delirium, or coma is defined as heat stroke. Studies in humans and animals indicate that the heat shock responses of the host contribute to multiple organ injury and death during heat stroke. Heme oxygenase-1 (HO-1)—a stress-responsive enzyme that catabolizes heme into iron, carbon monoxide, and biliverdin—has an important role in the neuroprotective mechanism against ischemic stroke. Here, we investigated the role of endogenous HO-1 in heat-induced brain damage in rats. RT-PCR results revealed that levels of HO-1 mRNA peaked at 0 h after heat exposure and immunoblot analysis revealed that the maximal protein expression occurred at 1 h post-heat exposure. Subsequently, we detected the HO-1 expression in the cortical brain cells and revealed the neuronal cell morphology. In conclusion, HO-1 is a potent protective molecule against heat-induced brain damage. Manipulation of HO-1 may provide a potential therapeutic approach for heat-related diseases.
原文英語
頁(從 - 到)737-741
頁數5
期刊International Journal of Medical Sciences
12
發行號9
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • Medicine(all)

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