Heat acclimation decreased oxidative DNA damage resulting from exposure to high heat in an occupational setting

Yung Kai Huang, Che-Wei Lin, Chen Chen Chang, Pai Fen Chen, Chien Jen Wang, Yu Mei Hsueh, Hung Che Chiang

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Heat acclimation is a physiologically and biochemically adapted process when species transition from one environmental temperature to one of the increased temperature. There is very limited epidemiological evidence on the heat-related impacts during exposure to extremely high heat in an occupational environment. This study sought to identify a potential biomarker of heat acclimation and the burden of heat on the body. The aim of this study was to elucidate oxidative DNA damage and heat acclimation through a self-comparison study design in navy boiler tenders, subjects exposed to extremely high heat in an occupational setting. Fifty-eight male soldiers who work in a boiler room were recruited for this study. The subjects were initially assessed with a health examination and body composition assessment before sailing. In order to compare the within-subject differences before and after heat exposure, the index-related heat exposure was collected before and after a routine 5-h work shift and 7-day sailing. Urinary 8-hydroxy-20-deoxyguanosine (8-OHdG), a useful marker of oxidative DNA damage was the measurement by liquid chromatography/ tandem mass spectrometry. The median of the change in urinary 8-OHdG was 0.78 lg/g creatinine, as the urinary 8-OHdG after sailing was significantly higher than before sailing (p
原文英語
頁(從 - 到)4119-4126
頁數8
期刊European Journal of Applied Physiology
112
發行號12
DOIs
出版狀態已發佈 - 十二月 2012

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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