摘要

Objective: Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones. Methods: We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-and HRV follow-ups were measured and compared. Results: mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-compared to healthy controls. In correlation analysis, only IGF-was positively correlated with HRV in mTBI patients. Both HRV and IGF-were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients. Conclusions: We infer that HRV may be more significantly correlated with emotional disorders than is IGF-in mTBI patients. Significance: The study is relevant for specific diagnostic markers in mTBI patients.
原文英語
頁(從 - 到)1629-1638
期刊Clinical Neurophysiology
127
發行號2
DOIs
出版狀態已發佈 - 2016

指紋

Brain Concussion
Somatomedins
Heart Rate
Serum
Anxiety
Depression
Adrenocorticotropic Hormone
Equipment and Supplies
Melatonin
Neurotransmitter Agents
Hydrocortisone
Biomarkers

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

引用此文

@article{7531a33e433f4852b94b1af32453bb9a,
title = "Heart rate variability and serum level of insulin-like growth factor-1 are correlated with symptoms of emotional disorders in patients suffering a mild traumatic brain injury",
abstract = "Objective: Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones. Methods: We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-1 and HRV follow-ups were measured and compared. Results: mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-1 compared to healthy controls. In correlation analysis, only IGF-1 was positively correlated with HRV in mTBI patients. Both HRV and IGF-1 were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients. Conclusions: We infer that HRV may be more significantly correlated with emotional disorders than is IGF-1 in mTBI patients. Significance: The study is relevant for specific diagnostic markers in mTBI patients.",
keywords = "Autonomic nervous system (ANS), Emotional disorder, Heart rate variability (HRV), Insulin-like growth factor-1 (IGF-1), Mild traumatic brain injury (mTBI)",
author = "Sung, {Chih Wei} and Kai-Yun Chen and Yung-Hsiao Chiang and Wen-Ta Chiu and Ou, {Ju Chi} and Hsin-Chien Lee and Shin-Han Tsai and Jia-Wei Lin and Che-Ming Yang and Tsai, {Yan Rou} and Liao, {Kuo Hsing} and Chen, {Gunng Shinng} and Li, {Wei Jiun} and Jia-Yi Wang",
year = "2016",
doi = "10.1016/j.clinph.2015.08.006",
language = "English",
volume = "127",
pages = "1629--1638",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Heart rate variability and serum level of insulin-like growth factor-1 are correlated with symptoms of emotional disorders in patients suffering a mild traumatic brain injury

AU - Sung, Chih Wei

AU - Chen, Kai-Yun

AU - Chiang, Yung-Hsiao

AU - Chiu, Wen-Ta

AU - Ou, Ju Chi

AU - Lee, Hsin-Chien

AU - Tsai, Shin-Han

AU - Lin, Jia-Wei

AU - Yang, Che-Ming

AU - Tsai, Yan Rou

AU - Liao, Kuo Hsing

AU - Chen, Gunng Shinng

AU - Li, Wei Jiun

AU - Wang, Jia-Yi

PY - 2016

Y1 - 2016

N2 - Objective: Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones. Methods: We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-1 and HRV follow-ups were measured and compared. Results: mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-1 compared to healthy controls. In correlation analysis, only IGF-1 was positively correlated with HRV in mTBI patients. Both HRV and IGF-1 were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients. Conclusions: We infer that HRV may be more significantly correlated with emotional disorders than is IGF-1 in mTBI patients. Significance: The study is relevant for specific diagnostic markers in mTBI patients.

AB - Objective: Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones. Methods: We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-1 and HRV follow-ups were measured and compared. Results: mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-1 compared to healthy controls. In correlation analysis, only IGF-1 was positively correlated with HRV in mTBI patients. Both HRV and IGF-1 were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients. Conclusions: We infer that HRV may be more significantly correlated with emotional disorders than is IGF-1 in mTBI patients. Significance: The study is relevant for specific diagnostic markers in mTBI patients.

KW - Autonomic nervous system (ANS)

KW - Emotional disorder

KW - Heart rate variability (HRV)

KW - Insulin-like growth factor-1 (IGF-1)

KW - Mild traumatic brain injury (mTBI)

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DO - 10.1016/j.clinph.2015.08.006

M3 - Article

VL - 127

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JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

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