Heart failure differentially modulates natural (Sinoatrial node) and ectopic (pulmonary veins) pacemakers: Mechanism and therapeutic implication for atrial fibrillation

Chao Shun Chan, Yung Kuo Lin, Yao Chang Chen, Yen Yu Lu, Shih Ann Chen, Yi Jen Chen

研究成果: 雜誌貢獻回顧型文獻

摘要

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF.
原文英語
文章編號3224
期刊International Journal of Molecular Sciences
20
發行號13
DOIs
出版狀態已發佈 - 七月 1 2019

指紋

fibrillation
Pacemakers
Sinoatrial Node
Pulmonary Veins
veins
Atrial Fibrillation
Heart Failure
adrenergics
Therapeutics
sinuses
Sick Sinus Syndrome
Crosstalk
fibrosis
Atrial Pressure
Adrenergic Agents
Calcium
crosstalk
stimulation
Chemical activation
calcium

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

引用此文

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title = "Heart failure differentially modulates natural (Sinoatrial node) and ectopic (pulmonary veins) pacemakers: Mechanism and therapeutic implication for atrial fibrillation",
abstract = "Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF.",
keywords = "Atrial fibrillation, Heart failure, Pulmonary veins, Sinoatrial node, Sinoatrial node dysfunction",
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T1 - Heart failure differentially modulates natural (Sinoatrial node) and ectopic (pulmonary veins) pacemakers

T2 - Mechanism and therapeutic implication for atrial fibrillation

AU - Chan, Chao Shun

AU - Lin, Yung Kuo

AU - Chen, Yao Chang

AU - Lu, Yen Yu

AU - Chen, Shih Ann

AU - Chen, Yi Jen

PY - 2019/7/1

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N2 - Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF.

AB - Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF.

KW - Atrial fibrillation

KW - Heart failure

KW - Pulmonary veins

KW - Sinoatrial node

KW - Sinoatrial node dysfunction

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