Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

Kuo Ching Chao, Chun Chao Chang, Eddy Owaga, Chyi Huey Bai, Tzu chieh Huang, Wen Harn Pan, Jung Su Chang

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Objective: Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents. Design: A population-based, cross-sectional study. Setting: National Nutrition and Health Survey in Taiwan (2010–2011, adolescents). Subjects: Healthy adolescents aged 13–18 years. Results: In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,
原文英語
期刊Public Health Nutrition
19
發行號6
DOIs
出版狀態已發佈 - 四月 2016

指紋

Dyslipidemias
Alanine Transaminase
Biomarkers
Blood Viscosity
Nutrition Surveys
Erythropoiesis
Health Surveys
Serum
Taiwan
Healthy Volunteers
Cross-Sectional Studies
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

引用此文

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title = "Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents",
abstract = "Objective: Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents. Design: A population-based, cross-sectional study. Setting: National Nutrition and Health Survey in Taiwan (2010–2011, adolescents). Subjects: Healthy adolescents aged 13–18 years. Results: In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,",
keywords = "Alanine aminotransferase, Dyslipidaemia, Hb, Liver function, Taiwanese adolescents",
author = "Chao, {Kuo Ching} and Chang, {Chun Chao} and Eddy Owaga and Bai, {Chyi Huey} and Huang, {Tzu chieh} and Pan, {Wen Harn} and Chang, {Jung Su}",
year = "2016",
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T1 - Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

AU - Chao, Kuo Ching

AU - Chang, Chun Chao

AU - Owaga, Eddy

AU - Bai, Chyi Huey

AU - Huang, Tzu chieh

AU - Pan, Wen Harn

AU - Chang, Jung Su

PY - 2016/4

Y1 - 2016/4

N2 - Objective: Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents. Design: A population-based, cross-sectional study. Setting: National Nutrition and Health Survey in Taiwan (2010–2011, adolescents). Subjects: Healthy adolescents aged 13–18 years. Results: In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,

AB - Objective: Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents. Design: A population-based, cross-sectional study. Setting: National Nutrition and Health Survey in Taiwan (2010–2011, adolescents). Subjects: Healthy adolescents aged 13–18 years. Results: In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,

KW - Alanine aminotransferase

KW - Dyslipidaemia

KW - Hb

KW - Liver function

KW - Taiwanese adolescents

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