Hair lead, aluminum, and other toxic metals in normal-weight and obese patients with coronary heart disease

Anatoly V. Skalny, Philippe Yu Kopylov, Monica M.B. Paoliello, Jung Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.J. Chao, Jan Aaseth, Sergei N. Chebotarev, Alexey A. Tinkov

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1 引文 斯高帕斯(Scopus)

摘要

The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control (n = 123) and obese groups (n = 140). Patients suffering from CHD were divided into normal weight (n = 180) and obese CHD subjects (n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.
原文英語
文章編號8195
期刊International journal of environmental research and public health
18
發行號15
DOIs
出版狀態已發佈 - 8月 2021

ASJC Scopus subject areas

  • 污染
  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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