Guidance for the Procurement of COVID-19 Convalescent Plasma: Differences between High and Low-Middle Income Countries

Evan M. Bloch, Ruchika Goel, Silvano Wendel, Thierry Burnouf, Arwa Z. Al-Riyami, Ai Leen Ang, Vincenzo DeAngelis, Larry J. Dumont, Kevin Land, Cheuk kwong Lee, Adaeze Oreh, Gopal Patidar, Steven L. Spitalnik, Marion Vermeulen, Salwa Hindawi, Karin Van den Berg, Pierre Tiberghien, Hans Vrielink, Pampee Young, Dana DevineCynthia So – Osman

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Background and Objectives: COVID-19 convalescent plasma (CCP) has been used, predominantly in high-income countries (HICs) to treat COVID-19; available data suggest the safety and efficacy of use. We sought to develop guidance for procurement and use of CCP, particularly in low and middle-income countries (LMICs) for which data are lacking. Materials and Methods: A multidisciplinary, geographically representative group of individuals with expertise spanning transfusion medicine, infectious diseases and hematology was tasked with the development of a guidance document for CCP, drawing on expert opinion, survey of group members and review of available evidence. Three subgroups (i.e. donor, product and patient) were established based on self-identified expertise and interest. Here, the donor and product-related challenges are summarized and contrasted between HICs and LMICs with a view to guide related practices. Results: The challenges to advance CCP therapy are different between HICs and LMICs. Early challenges in HICs related to recruitment and qualification of sufficient donors to meet the growing demand. Antibody testing also posed a specific obstacle given lack of standardization, variable performance of the assays in use and uncertain interpretation of results. In LMICs, an extant transfusion deficit, suboptimal models of donor recruitment (e.g. reliance on replacement and paid donors), limited laboratory capacity for pre-donation qualification and operational considerations could impede wide adoption. Conclusion: There has been wide scale adoption of CCP in many HICs, which could increase if clinical trials show efficacy of use. By contrast, LMICs, having received little attention, require locally applicable strategies for adoption of CCP.

原文英語
期刊Vox Sanguinis
DOIs
出版狀態接受/付印 - 2020

ASJC Scopus subject areas

  • Hematology

指紋 深入研究「Guidance for the Procurement of COVID-19 Convalescent Plasma: Differences between High and Low-Middle Income Countries」主題。共同形成了獨特的指紋。

  • 引用此

    Bloch, E. M., Goel, R., Wendel, S., Burnouf, T., Al-Riyami, A. Z., Ang, A. L., DeAngelis, V., Dumont, L. J., Land, K., Lee, C. K., Oreh, A., Patidar, G., Spitalnik, S. L., Vermeulen, M., Hindawi, S., Van den Berg, K., Tiberghien, P., Vrielink, H., Young, P., ... So – Osman, C. (認可的出版社/出版中). Guidance for the Procurement of COVID-19 Convalescent Plasma: Differences between High and Low-Middle Income Countries. Vox Sanguinis. https://doi.org/10.1111/vox.12970