Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression

Chemin Lin, Chih Mao Huang, Helmet T. Karim, Ho Ling Liu, Tatia Mei Chun Lee, Changwei W. Wu, Cheng Hong Toh, Yun Fang Tsai, Tzung Hai Yen, Shwu Hua Lee

研究成果: 雜誌貢獻文章同行評審

摘要

Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.

原文英語
頁(從 - 到)60-67
頁數8
期刊Neurobiology of Aging
103
DOIs
出版狀態已發佈 - 七月 2021

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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