@article{477e060e7f7e4f02a910ae6844457a9f,
title = "Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression",
abstract = "Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.",
keywords = "Cognitive function, Late-life depression, Periventricular white matter hyperintensity, Suicide, White matter hyperintensity",
author = "Chemin Lin and Huang, {Chih Mao} and Karim, {Helmet T.} and Liu, {Ho Ling} and Lee, {Tatia Mei Chun} and Wu, {Changwei W.} and Toh, {Cheng Hong} and Tsai, {Yun Fang} and Yen, {Tzung Hai} and Lee, {Shwu Hua}",
note = "Funding Information: All data is available by request. All authors declare that no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work; and (ii) there are no other relationships or activities that could appear to have influenced the submitted work. This study was approved by the Chang Gung Memorial Hospital Institutional Review Board and all participants gave written informed consent prior to participation. This study was supported by funding from Supported by (1) medical research grants CRRPG2K0021 from Chang Gung Memorial Hospital and NRRPG2H0031 from Ministry of Science and Technology, Taiwan to Chemin Lin (2) NMRPG3G6031/32 and NMRPG3J0121 from Ministry of Science and Technology, Taiwan to Shwu-Hua, Lee (3) the KKHo International Charitable Foundation to Tatia Lee. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jul,
doi = "10.1016/j.neurobiolaging.2020.12.016",
language = "English",
volume = "103",
pages = "60--67",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}
