Granulomatous nasopharyngeal carcinoma: with emphasis on difficulty in diagnosis and favorable outcome.

C. L. Chen, I. J. Su, M. M. Hsu, H. C. Hsu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Nasopharyngeal carcinoma (NPC) can provoke a local granulomatous reaction which may cause diagnostic difficulty. To further elucidate this possible diagnostic pitfall, 47 cases who were initially diagnosed as tuberculosis or granulomatous inflammation were reexamined; 7 cases (15%) were found to have NPC. In a routine histological stain, residual malignant tumor cells could be identified in 2 cases. In the remaining 5 cases, malignant tumor cells could only be accurately identified after careful examination. Immunohistochemical staining for keratin easily demonstrated the residual tumor cells engulfed in a granulomatous lesion in all 7 cases. This finding suggests that an immunohistochemical stain for keratin is useful and should be performed for any nasopharyngeal biopsy showing granulomatous lesion with suspicion of malignancy, particularly in countries where NPC is prevalent. The overall 5-year survival rate among these NPC patients was 83%, a most favorable outcome, which suggests that a granulomatous reaction may reflect a favorable local host, and a cell-mediated immune response.

原文英語
頁(從 - 到)353-356
頁數4
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
90
發行號4
出版狀態已發佈 - 四月 1991
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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