GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles

Tsung Hsien Lee, Ming Yih Wu, Hsin Fu Chen, Mei Jou Chen, Hong Nerng Ho, Yu Shih Yang

研究成果: 雜誌貢獻文章

摘要

The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.
原文英語
頁(從 - 到)93-96
頁數4
期刊International Congress Series
1271
發行號C
DOIs
出版狀態已發佈 - 九月 1 2004
對外發佈Yes

指紋

Pregnancy Rate
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Nitric Oxide
Pregnancy
Embryonic Structures
Buserelin
Intracytoplasmic Sperm Injections
Serum

ASJC Scopus subject areas

  • Medicine(all)

引用此文

GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles. / Lee, Tsung Hsien; Wu, Ming Yih; Chen, Hsin Fu; Chen, Mei Jou; Ho, Hong Nerng; Yang, Yu Shih.

於: International Congress Series, 卷 1271, 編號 C, 01.09.2004, p. 93-96.

研究成果: 雜誌貢獻文章

Lee, Tsung Hsien ; Wu, Ming Yih ; Chen, Hsin Fu ; Chen, Mei Jou ; Ho, Hong Nerng ; Yang, Yu Shih. / GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles. 於: International Congress Series. 2004 ; 卷 1271, 編號 C. 頁 93-96.
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AU - Wu, Ming Yih

AU - Chen, Hsin Fu

AU - Chen, Mei Jou

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

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N2 - The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.

AB - The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.

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KW - Nitric oxide

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