Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma

Yu Chuen Huang, Marcelo Chen, Yi Ming Shyr, Cheng Hsi Su, Chi Kuan Chen, Anna Fen Yau Li, Donald Ming Tak Ho, Yi Ming Arthur Chen

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Background and Aim: Glycine N-methyltransferase (GNMT) is a susceptibility gene for human hepatocellular carcinoma (HCC). We previously reported that GNMT expression is diminished in HCC. Here we report our examination of GNMT expression patterns in cholangiocarcinoma and the relationship between its expression and prognosis. Methods: We analyzed GNMT expression in tumor tissues from 33 cholangiocarcinoma patients (19 male) using immunohistochemistry (IHC) procedures with a GNMT monoclonal antibody (mAb 4-17). GNMT expression intensity and percentages were scored on a scale of 0 to 6. The association between GNMT expression and survival was analyzed using the Kaplan-Meier method, and prognostic factors were evaluated with a multivariate Cox proportional hazards regression model. Results: High GNMT expression was found in epithelial cells of normal bile ducts. Six of 33 (18.2%) cholangiocarcinoma tissues had no GNMT expression. A statistically significant difference was noted in GNMT expression between male and female patients (68.4% vs 100%, P < 0.05). Compared to patients with GNMT expression scores > 3, the death hazard ratio for patients with GNMT scores ≤ 3 was 3.68 (95% confidence interval = 1.17-11.59, P < 0.05). Conclusions: GNMT expression is a favorable prognosis predictor for cholangiocarcinoma.
原文英語
頁(從 - 到)1384-1389
頁數6
期刊Journal of Gastroenterology and Hepatology (Australia)
23
發行號9
DOIs
出版狀態已發佈 - 一月 1 2008
對外發佈

ASJC Scopus subject areas

  • 肝病
  • 消化內科

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