Glycated albumin predicts long-term survival in patients undergoing hemodialysis

Chien Lin Lu, Wen Ya Ma, Yuh Feng Lin, Jia Fwu Shyu, Yuan Hung Wang, Yueh Min Liu, Chia Chao Wu, Kuo Cheng Lu

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0% for each 1% increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis.
原文英語
頁(從 - 到)395-402
頁數8
期刊International Journal of Medical Sciences
13
發行號5
DOIs
出版狀態已發佈 - 五月 10 2016

指紋

Renal Dialysis
Survival
glycosylated serum albumin
Kaplan-Meier Estimate
Proportional Hazards Models
Serum Albumin
ROC Curve
Blood Glucose
Hemoglobins
Survival Rate
Maintenance
Kidney
Mortality

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Glycated albumin predicts long-term survival in patients undergoing hemodialysis. / Lu, Chien Lin; Ma, Wen Ya; Lin, Yuh Feng; Shyu, Jia Fwu; Wang, Yuan Hung; Liu, Yueh Min; Wu, Chia Chao; Lu, Kuo Cheng.

於: International Journal of Medical Sciences, 卷 13, 編號 5, 10.05.2016, p. 395-402.

研究成果: 雜誌貢獻文章

Lu, Chien Lin ; Ma, Wen Ya ; Lin, Yuh Feng ; Shyu, Jia Fwu ; Wang, Yuan Hung ; Liu, Yueh Min ; Wu, Chia Chao ; Lu, Kuo Cheng. / Glycated albumin predicts long-term survival in patients undergoing hemodialysis. 於: International Journal of Medical Sciences. 2016 ; 卷 13, 編號 5. 頁 395-402.
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abstract = "Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0{\%} for each 1{\%} increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis.",
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AU - Ma, Wen Ya

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AU - Liu, Yueh Min

AU - Wu, Chia Chao

AU - Lu, Kuo Cheng

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N2 - Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0% for each 1% increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis.

AB - Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0% for each 1% increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis.

KW - Glycated albumin

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