Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer

Mu Kuan Chen, Hsiu Ting Tsai, Tsung Te Chung, Shih Chi Su, Te Yu Kao, Hsien Chun Tseng, Te Hsiung Liu, Hui Ling Chiou, Shun Fa Yang

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29 引文 斯高帕斯(Scopus)

摘要

Background. The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk. Methods. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients. Results. Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes. Conclusions. The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.

原文英語
頁(從 - 到)1079-1087
頁數9
期刊Head and Neck
32
發行號8
DOIs
出版狀態已發佈 - 八月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Otorhinolaryngology

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