Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

Chia Jung Liao, Tzu I. Wu, Ya Hui Huang, Ting Chang Chang, Chia Siu Wang, Ming Ming Tsai, Chyong Huey Lai, Ying Liang, Shih Ming Jung, Kwang Huei Lin

研究成果: 雜誌貢獻文章

25 引文 (Scopus)

摘要

Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P

原文英語
頁(從 - 到)2255-2263
頁數9
期刊Cancer Science
102
發行號12
DOIs
出版狀態已發佈 - 十二月 2011
對外發佈Yes

指紋

Papillomaviridae
Uterine Cervical Neoplasms
Glucose
Electrophoresis, Gel, Two-Dimensional
Virus Diseases
Immunoblotting
Proteomics
Squamous Cell Carcinoma
Carcinogenesis
Proteins
Adenocarcinoma
Staining and Labeling
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer. / Liao, Chia Jung; Wu, Tzu I.; Huang, Ya Hui; Chang, Ting Chang; Wang, Chia Siu; Tsai, Ming Ming; Lai, Chyong Huey; Liang, Ying; Jung, Shih Ming; Lin, Kwang Huei.

於: Cancer Science, 卷 102, 編號 12, 12.2011, p. 2255-2263.

研究成果: 雜誌貢獻文章

Liao, CJ, Wu, TI, Huang, YH, Chang, TC, Wang, CS, Tsai, MM, Lai, CH, Liang, Y, Jung, SM & Lin, KH 2011, 'Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer', Cancer Science, 卷 102, 編號 12, 頁 2255-2263. https://doi.org/10.1111/j.1349-7006.2011.02102.x
Liao, Chia Jung ; Wu, Tzu I. ; Huang, Ya Hui ; Chang, Ting Chang ; Wang, Chia Siu ; Tsai, Ming Ming ; Lai, Chyong Huey ; Liang, Ying ; Jung, Shih Ming ; Lin, Kwang Huei. / Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer. 於: Cancer Science. 2011 ; 卷 102, 編號 12. 頁 2255-2263.
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abstract = "Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73{\%} of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P",
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AU - Huang, Ya Hui

AU - Chang, Ting Chang

AU - Wang, Chia Siu

AU - Tsai, Ming Ming

AU - Lai, Chyong Huey

AU - Liang, Ying

AU - Jung, Shih Ming

AU - Lin, Kwang Huei

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