Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila

Zhao Ying Ding, Ying Hsuan Wang, Zhao Kai Luo, Huei Fang Lee, Jaulang Hwang, Cheng Ting Chien, Min Lang Huang

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4 引文 斯高帕斯(Scopus)


Axon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzipD43 mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance.

頁(從 - 到)122-134
期刊Developmental Dynamics
出版狀態已發佈 - 1月 2011

ASJC Scopus subject areas

  • 發展生物學


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