Germline genetic association between stromal interaction molecule 1 (STIM1) and clinical outcomes in breast cancer patients

Chi Cheng Huang, Min Rou Lin, Yu Chen Yang, Yu Wen Hsu, Henry Sung Ching Wong, Wei Chiao Chang

研究成果: 雜誌貢獻文章同行評審

摘要

Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium (SOC) channels, which control calcium signaling and cell proliferation pathways. Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. However, the clinical relevance of STIM1 in breast cancer is still unclear. Here, we recruited 348 breast cancer patients and conducted a genetic association study to address this question. Four tagging germline single nucleotide variants (SNVs) in STIM1 were selected and RNA sequencing data of 525 breast cancer samples from The Cancer Genome Atlas (TCGA) database were evaluated. The results show that rs2304891 and rs3750996 were correlated with clinical stage of breast cancer. Expression quantitative trait loci (eQTL) analysis indicated that risk G allele of STIM1 contributed to the higher expression of STIM1. In addition, we found an increased risk of rs2304891 G allele and rs3750996 A allele in estrogen receptor (ER) positive and progesterone receptor (PR) positive patients. In conclusion, our results suggest that germline SNV, rs2304891 and rs3750996 as well as STIM1 expression are important biomarkers for the prediction of clinical outcomes in breast cancer patients.

原文英語
文章編號287
頁(從 - 到)1-12
頁數12
期刊Journal of Personalized Medicine
10
發行號4
DOIs
出版狀態已發佈 - 十二月 2020

ASJC Scopus subject areas

  • 醫藥(雜項)

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