Genotyping analysis of colonizing candidal isolates from very-low-birthweight infants in a neonatal intensive care unit

Y. C. Huang, L. H. Su, T. L. Wu, T. Y. Lin

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

To analyse the relatedness of colonizing candidal isolates from very-low-birthweight infants hospitalized in a neonatal intensive care unit (NICU), we prospectively collected 86 candidal isolates from 20 infants, including 67 isolates of Candida albicans from 15 infants, 17 isolates of Candida parapsilosis from five infants and two isolates of Candida glabrata from one infant, who also had C. albicans colonization, over a one-year period. All 86 isolates were genotyped by infrequent-restriction-site polymerase chain reaction (IRS-PCR) and electrophoretic karyotyping (EK) with pulsed-field gel electrophoresis. A total of 15 genotypes were identified by IRS-PCR and 12 genotypes by EK. Some infants shared a common genotype. From a single infant, an identical genotype was found in 11 of 13 cases where at least two isolates of same Candida species were available for genotyping analysis, regardless of anatomical site, how many isolates were recovered or how many times. Should an infant harbour a candidal strain, they may harbour this strain at multiple sites and for a prolonged period.
原文英語
頁(從 - 到)200-203
頁數4
期刊Journal of Hospital Infection
58
發行號3
DOIs
出版狀態已發佈 - 十一月 2004
對外發佈Yes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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