Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene

Yi Ming A. Chen, Li Ying Chen, Fen Hwa Wong, Cheng Ming Lee, Tai Jay Chang, Teresa L. Yang-Feng

研究成果: 雜誌貢獻文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S- adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. Previously, we reported that the expression level of GNMT was diminished in human hepatocellular carcinoma. In this study, the human GNMT gene was cloned and characterized. It contains six exons and spans about 10 kb. Instead of a TATA box, it has a transcriptional initiator located 801 bp upstream from the translation start codon. The gene was localized to chromosome 6p12 using fluorescence in situ hybridization. Northern blot analysis of 16 tissues from different human organs showed that GNMT was expressed only in liver, pancreas, and prostate. (C) 2000 Academic Press.
原文英語
頁(從 - 到)43-47
頁數5
期刊Genomics
66
發行號1
DOIs
出版狀態已發佈 - 五月 15 2000
對外發佈Yes

ASJC Scopus subject areas

  • Genetics

指紋 深入研究「Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene」主題。共同形成了獨特的指紋。

引用此