Genetic variations of melatonin receptor type 1a are associated with the clinicopathologic development of urothelial cell carcinoma

Yung Wei Lin, Shian Shiang Wang, Yu Ching Wen, Min Che Tung, Liang Ming Lee, Shun Fa Yang, Ming Hsien Chien

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types in vitro and in vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A), and genetic variations of MTNR1A affect the susceptibility several diseases and cancer. The purpose of this study was to explore the effect of MTNR1A gene polymorphisms on the susceptibility to and clinicopathological characteristics of urothelial cell carcinoma (UCC). We recruited 272 patients with UCC and 272 normal controls to analyze three common single-nucleotide polymorphisms (SNPs) (rs2119882, rs13140012, and rs6553010) of MTNR1A related to cancer risk and clinicopathological relevance according to a TaqMan-based real-time polymerase chain reaction (PCR). We found that these three SNPs of MTNR1A were not associated with UCC susceptibility. However, patients with UCC who had at least one G allele of MTNR1A rs6553010 (in intron 1) were at higher risk (1.768-fold, 95% confidence interval: 1.068~1.849) of developing an invasive stage (p < 0.026), compared to those patients with AA homozygotes. In conclusion, polymorphic genotypes of rs6553010 of MTNR1A might contribute to the ability to predict aggressive phenotypes of UCC. This is the first study to provide insights into risk factors associated with intronic MTNR1A variants in the clinicopathologic development of UCC in Taiwan.
原文英語
頁(從 - 到)1130-1135
頁數6
期刊International Journal of Medical Sciences
14
發行號11
DOIs
出版狀態已發佈 - 九月 4 2017

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Genetic variations of melatonin receptor type 1a are associated with the clinicopathologic development of urothelial cell carcinoma」主題。共同形成了獨特的指紋。

  • 引用此