Genetic variants associated with serum alanine aminotransferase levels among patients with hepatitis C virus infection: A genome-wide association study

Po Chun Liu, Chi Chan, Yu Han Huang, Yen Ju Chen, Shu Fen Liao, Yu Ju Lin, Claire Huang, Sheng Nan Lu, Chin Lan Jen, Li Yu Wang, Hwai I. Yang, Chen Yang Shen, Chien Jen Chen, Mei Hsuan Lee

研究成果: 雜誌貢獻文章同行評審

摘要

Information on genetic variants associated with elevated serum alanine aminotransferase (ALT) levels remains limited. A genome-wide association study was performed to identify single-nucleotide polymorphisms (SNPs) associated with ALT levels. The ALT-associated SNP was further evaluated for hepatocellular carcinoma (HCC) risk. A cohort of 892 anti-HCV seropositive patients was used for genome-wide SNP array to examine the associations with baseline ALT levels. SNPs 15 U/L but never >45 U/L, and 318 (39.6%) ever >45 U/L during follow-up. The rs568800 was associated with serial ALT levels, and this was replicated in the external population significantly (p 15 U/L but ≤45 U/L and ALT >45 U/L, with the adjusted ORs of 1.41 (1.11–1.78) and 1.86 (1.34–2.60), respectively. The adjusted HRs for HCC were 2.09 (0.90–4.89) for AC and 2.64 (1.13–6.17) for AA (CC as a reference). In conclusion, the rs568800 was associated with serum ALT levels and HCC risk. Clinical utility should be evaluated among patients who have received antivirals.
原文英語
頁(從 - 到)1265-1273
頁數9
期刊Journal of Viral Hepatitis
28
發行號9
DOIs
出版狀態已發佈 - 9月 2021
對外發佈

ASJC Scopus subject areas

  • 肝病
  • 傳染性疾病
  • 病毒學

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