摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 311-319 |
| 頁數 | 9 |
| 期刊 | International Journal of Cancer |
| 卷 | 137 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 七月 15 2015 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
引用此文
Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia : A report from the female lung cancer consortium in Asia. / Machiela, Mitchell J.; Hsiung, Chao Agnes; Shu, Xiao Ou; Seow, Wei Jie; Wang, Zhaoming; Matsuo, Keitaro; Hong, Yun Chul; Seow, Adeline; Wu, Chen; Hosgood, H. Dean; Chen, Kexin; Wang, Jiu Cun; Wen, Wanqing; Cawthon, Richard; Chatterjee, Nilanjan; Hu, Wei; Caporaso, Neil E.; Park, Jae Yong; Chen, Chien Jen; Kim, Yeul Hong; Kim, Young Tae; Landi, Maria Teresa; Shen, Hongbing; Lawrence, Charles; Burdett, Laurie; Yeager, Meredith; Chang, I. Shou; Mitsudomi, Tetsuya; Kim, Hee Nam; Chang, Gee Chen; Bassig, Bryan A.; Tucker, Margaret; Wei, Fusheng; Yin, Zhihua; An, She Juan; Qian, Biyun; Lee, Victor Ho Fun; Lu, Daru; Liu, Jianjun; Jeon, Hyo Sung; Hsiao, Chin Fu; Sung, Jae Sook; Kim, Jin Hee; Gao, Yu Tang; Tsai, Ying Huang; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Hutchinson, Amy; Wang, Wen Chang; Klein, Robert J.; Chung, Charles C.; Oh, In Jae; Chen, Kuan Yu; Berndt, Sonja I.; Wu, Wei; Chang, Jiang; Zhang, Xu Chao; Huang, Ming Shyan; Zheng, Hong; Wang, Junwen; Zhao, Xueying; Li, Yuqing; Choi, Jin Eun; Su, Wu Chou; Park, Kyong Hwa; Sung, Sook Whan; Chen, Yuh Min; Liu, Li; Kang, Chang Hyun; Hu, Lingmin; Chen, Chung Hsing; Pao, William; Kim, Young Chul; Yang, Tsung Ying; Xu, Jun; Guan, Peng; Tan, Wen; Su, Jian; Wang, Chih Liang; Li, Haixin; Sihoe, Alan Dart Loon; Zhao, Zhenhong; Chen, Ying; Choi, Yi Young; Hung, Jen Yu; Kim, Jun Suk; Yoon, Ho Il; Cai, Qiuyin; Lin, Chien Chung; Park, In Kyu; Xu, Ping; Dong, Jing; Kim, Christopher; He, Qincheng; Perng, Reury Perng; Kohno, Takashi; Kweon, Sun Seog; Chen, Chih Yi; Vermeulen, Roel C H; Wu, Junjie; Lim, Wei Yen; Chen, Kun Chieh; Chow, Wong Ho; Ji, Bu Tian; Chan, John K C; Chu, Minjie; Li, Yao Jen; Yokota, Jun; Li, Jihua; Chen, Hongyan; Xiang, Yong Bing; Yu, Chong Jen; Kunitoh, Hideo; Wu, Guoping; Jin, Li; Lo, Yen Li; Shiraishi, Kouya; Chen, Ying Hsiang; Lin, Hsien Chih; Wu, Tangchun; Wong, Maria Pik; Wu, Yi Long; Yang, Pan Chyr; Zhou, Baosen; Shin, Min Ho; Fraumeni, Joseph F.; Zheng, Wei; Lin, Dongxin; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing.
於: International Journal of Cancer, 卷 137, 編號 2, 15.07.2015, p. 311-319.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia
T2 - A report from the female lung cancer consortium in Asia
AU - Machiela, Mitchell J.
AU - Hsiung, Chao Agnes
AU - Shu, Xiao Ou
AU - Seow, Wei Jie
AU - Wang, Zhaoming
AU - Matsuo, Keitaro
AU - Hong, Yun Chul
AU - Seow, Adeline
AU - Wu, Chen
AU - Hosgood, H. Dean
AU - Chen, Kexin
AU - Wang, Jiu Cun
AU - Wen, Wanqing
AU - Cawthon, Richard
AU - Chatterjee, Nilanjan
AU - Hu, Wei
AU - Caporaso, Neil E.
AU - Park, Jae Yong
AU - Chen, Chien Jen
AU - Kim, Yeul Hong
AU - Kim, Young Tae
AU - Landi, Maria Teresa
AU - Shen, Hongbing
AU - Lawrence, Charles
AU - Burdett, Laurie
AU - Yeager, Meredith
AU - Chang, I. Shou
AU - Mitsudomi, Tetsuya
AU - Kim, Hee Nam
AU - Chang, Gee Chen
AU - Bassig, Bryan A.
AU - Tucker, Margaret
AU - Wei, Fusheng
AU - Yin, Zhihua
AU - An, She Juan
AU - Qian, Biyun
AU - Lee, Victor Ho Fun
AU - Lu, Daru
AU - Liu, Jianjun
AU - Jeon, Hyo Sung
AU - Hsiao, Chin Fu
AU - Sung, Jae Sook
AU - Kim, Jin Hee
AU - Gao, Yu Tang
AU - Tsai, Ying Huang
AU - Jung, Yoo Jin
AU - Guo, Huan
AU - Hu, Zhibin
AU - Hutchinson, Amy
AU - Wang, Wen Chang
AU - Klein, Robert J.
AU - Chung, Charles C.
AU - Oh, In Jae
AU - Chen, Kuan Yu
AU - Berndt, Sonja I.
AU - Wu, Wei
AU - Chang, Jiang
AU - Zhang, Xu Chao
AU - Huang, Ming Shyan
AU - Zheng, Hong
AU - Wang, Junwen
AU - Zhao, Xueying
AU - Li, Yuqing
AU - Choi, Jin Eun
AU - Su, Wu Chou
AU - Park, Kyong Hwa
AU - Sung, Sook Whan
AU - Chen, Yuh Min
AU - Liu, Li
AU - Kang, Chang Hyun
AU - Hu, Lingmin
AU - Chen, Chung Hsing
AU - Pao, William
AU - Kim, Young Chul
AU - Yang, Tsung Ying
AU - Xu, Jun
AU - Guan, Peng
AU - Tan, Wen
AU - Su, Jian
AU - Wang, Chih Liang
AU - Li, Haixin
AU - Sihoe, Alan Dart Loon
AU - Zhao, Zhenhong
AU - Chen, Ying
AU - Choi, Yi Young
AU - Hung, Jen Yu
AU - Kim, Jun Suk
AU - Yoon, Ho Il
AU - Cai, Qiuyin
AU - Lin, Chien Chung
AU - Park, In Kyu
AU - Xu, Ping
AU - Dong, Jing
AU - Kim, Christopher
AU - He, Qincheng
AU - Perng, Reury Perng
AU - Kohno, Takashi
AU - Kweon, Sun Seog
AU - Chen, Chih Yi
AU - Vermeulen, Roel C H
AU - Wu, Junjie
AU - Lim, Wei Yen
AU - Chen, Kun Chieh
AU - Chow, Wong Ho
AU - Ji, Bu Tian
AU - Chan, John K C
AU - Chu, Minjie
AU - Li, Yao Jen
AU - Yokota, Jun
AU - Li, Jihua
AU - Chen, Hongyan
AU - Xiang, Yong Bing
AU - Yu, Chong Jen
AU - Kunitoh, Hideo
AU - Wu, Guoping
AU - Jin, Li
AU - Lo, Yen Li
AU - Shiraishi, Kouya
AU - Chen, Ying Hsiang
AU - Lin, Hsien Chih
AU - Wu, Tangchun
AU - Wong, Maria Pik
AU - Wu, Yi Long
AU - Yang, Pan Chyr
AU - Zhou, Baosen
AU - Shin, Min Ho
AU - Fraumeni, Joseph F.
AU - Zheng, Wei
AU - Lin, Dongxin
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Lan, Qing
PY - 2015/7/15
Y1 - 2015/7/15
N2 - Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10-14) even after removing rs2736100 (p value = 4.81 × 10-3), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.
AB - Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10-14) even after removing rs2736100 (p value = 4.81 × 10-3), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.
KW - association study
KW - genetic risk score
KW - genetics
KW - lung cancer
KW - telomere length
UR - http://www.scopus.com/inward/record.url?scp=84929238718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929238718&partnerID=8YFLogxK
U2 - 10.1002/ijc.29393
DO - 10.1002/ijc.29393
M3 - Article
C2 - 25516442
AN - SCOPUS:84929238718
VL - 137
SP - 311
EP - 319
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -