Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients

James Cheng Chung Wei, Kuo Sheng Hung, Yu Wen Hsu, Ruey Hong Wong, Chun Huang Huang, Ming Shiou Jan, Shyh Jong Wu, Yung Shun Juan, Wei Chiao Chang

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.

原文英語
文章編號e49698
期刊PLoS One
7
發行號12
DOIs
出版狀態已發佈 - 十二月 14 2012

指紋

erythrocyte sedimentation rate
HLA-B27 Antigen
Blood Sedimentation
Ankylosing Spondylitis
C-reactive protein
Genetic Polymorphisms
Polymorphism
Sedimentation
C-Reactive Protein
genetic polymorphism
Molecules
inflammation
alleles
HLA Antigens
single nucleotide polymorphism
haplotypes
pathogenesis
Nucleotides
Genes
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients. / Wei, James Cheng Chung; Hung, Kuo Sheng; Hsu, Yu Wen; Wong, Ruey Hong; Huang, Chun Huang; Jan, Ming Shiou; Wu, Shyh Jong; Juan, Yung Shun; Chang, Wei Chiao.

於: PLoS One, 卷 7, 編號 12, e49698, 14.12.2012.

研究成果: 雜誌貢獻文章

Wei, James Cheng Chung ; Hung, Kuo Sheng ; Hsu, Yu Wen ; Wong, Ruey Hong ; Huang, Chun Huang ; Jan, Ming Shiou ; Wu, Shyh Jong ; Juan, Yung Shun ; Chang, Wei Chiao. / Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients. 於: PLoS One. 2012 ; 卷 7, 編號 12.
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abstract = "Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.",
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