Genetic polymorphisms of myeloperoxidase and their effect on hypertension

Yi Chien Liu, Chi Jung Chung, Horng Sheng Shiue, Ya Yun Cheng, Shiau Rung Huang, Chien Tien Su, Yu Mei Hsueh

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Myeloperoxidase (MPO) is a member of the mammalian peroxidase superfamily and plays specific roles in host defense. This study aimed to explore the association between one polymorphism of MPO and hypertension risk. Study subjects were recruited from Taipei City Hospital, Zhongxiao Branch, Taipei Medical University Hospital and Taipei Municipal WanFang Hospital. Participants completed questionnaires and provided blood samples. In this study we considered hypertension to be present among subjects that had blood pressures above 140/90 mmHg, or who had previously received treatment for hypertension. The polymorphism of MPO investigated in this study was constructed by performing a restriction fragment length polymorphism following polymerase chain reaction. This study found the odds ratio and 95% confidence interval for hypertension among subjects with the MPO -463 GA/AA genotype to be 1.97 (1.23-3.16) when compared with those with the GG genotype after multivariate adjustment. Participants with a body mass index (BMI) ≥ 24 kg/m2 and with MPO -463 GA/AA genotype had a 4.60-fold increased risk of hypertension compared with those with a BMI <24 kg/m2 and with the GG genotype. This is the first study to conclude that the MPO -463 GA/AA genotype was associated with hypertension. In addition, we also detected that subjects with the MPO -463 GA/AA genotype that had higher BMIs and positive diabetes status tended to have higher risks of hypertension than subjects with the MPO -463 GA/AA genotype that had normal BMIs and were not diabetic.

原文英語
頁(從 - 到)282-289
頁數8
期刊Blood Pressure
22
發行號5
DOIs
出版狀態已發佈 - 十月 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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