Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy

Hui Ting Yang, Ruey Yun Wang, Shih-Yi Huang, Chieh Liang Huang, Kuan Pin Su

研究成果: 雜誌貢獻文章同行評審

摘要

Abnormal fatty acid metabolism and the related enzymes had been observed to be associated with psychiatric disorders. We investigated FADS gene family genetic polymorphisms and variations of lipid profiles in patients with heroin dependence receiving 6-month methadone maintenance therapy (MMT). We recruited 89 MMT drug abusers and analyzed 3 tag single nucleotide polymorphisms (SNPs) from Fatty acid desaturases (FADS), FADS1, FADS2 and FADS3. The fatty acid profiles of erythrocyte membranes were analyzed based on genetic variations. Six-month MMT therapy were significantly associated with decreased C20: 5n3 and C22:4n6 levels in the whole group of drug abusers. The decreases of C22: 6n3 after MMT therapy were associated with specific genetic variations, including FADS1 C/C, FADS2 T/T and FADS3 C/C genotypes. The variations on n3 and n6 PUFA composition were significantly shown in different alleles of FADS in MMT drug abusers. Further studies are needed to elucidate the role of fatty acid metabolism on rehabilitation by MMT.
原文英語
頁(從 - 到)117-121
頁數5
期刊Prostaglandins Leukotrienes and Essential Fatty Acids
136
DOIs
出版狀態已發佈 - 2018

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

指紋 深入研究「Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy」主題。共同形成了獨特的指紋。

引用此