Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan

Yen Ching Chen, Lilian Xu, Yu Liang Leon Guo, Huey Jen Jenny Su, Yu Mei Hsueh, Thomas J. Smith, Louise M. Ryan, Meei Shyuan Lee, Sheau Chiou Chaor, Julia Yu Yun Lee, David C. Christiani

研究成果: 雜誌貢獻文章

31 引文 (Scopus)

摘要

The Pro/Pro polymorphism of p53 codon 72 has been reported to be related to bladder and lung cancer, but its relationship with skin cancer is unclear. We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan. From 1996 to 1999, 93 newly-diagnosed skin cancer patients at the National Cheng-Kung University (NCKU) Hospital and 71 community controls matched on residence were recruited in southwestern Taiwan. The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). A questionnaire was administered to each subject for collection of demographic information, personal habits, disease history, diet information, and other relevant questions. The Pro/Pro (homozygous) genotype was more frequent in skin cancer patients (cases, 20%; controls, 12%; P = 0.37). Subjects with the susceptible genotype Pro/Pro and heterozygous (intermediate) genotype Pro/Arg had 2.18 and 0.99 times risk of skin cancer than the wild type Arg/Arg (95% confidence interval, 0.74-4.38; 95% confidence interval, 0.44-2.21), respectively. Compared with subjects with 18.5 <BMI <23, subjects with BMI > 18.5 had 5.78 times risk of skin cancer (95% confidence interval, 1.06 to 31.36) after adjusting for other risk factors. There was no interaction between BMI and genotype, but the sample size was small. The risk of skin cancer did not significantly vary by tumor cell-type. The risk of skin cancer is increased in individuals with the Pro/Pro genotype. Larger, confirmatory studies are needed to clarify the role of constitutional polymorphisms in p53 and skin cancer risk.

原文英語
頁(從 - 到)201-211
頁數11
期刊Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
38
發行號1
DOIs
出版狀態已發佈 - 2003

指紋

Polymorphism
cancer
skin
Skin
polymorphism
genotype
confidence interval
Polymerase chain reaction
Arsenic
Nutrition
risk factor
tumor
polymerase chain reaction
Tumors
arsenic
Cells
diet
history

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

引用此文

Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan. / Chen, Yen Ching; Xu, Lilian; Guo, Yu Liang Leon; Su, Huey Jen Jenny; Hsueh, Yu Mei; Smith, Thomas J.; Ryan, Louise M.; Lee, Meei Shyuan; Chaor, Sheau Chiou; Lee, Julia Yu Yun; Christiani, David C.

於: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 卷 38, 編號 1, 2003, p. 201-211.

研究成果: 雜誌貢獻文章

Chen, Yen Ching ; Xu, Lilian ; Guo, Yu Liang Leon ; Su, Huey Jen Jenny ; Hsueh, Yu Mei ; Smith, Thomas J. ; Ryan, Louise M. ; Lee, Meei Shyuan ; Chaor, Sheau Chiou ; Lee, Julia Yu Yun ; Christiani, David C. / Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan. 於: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2003 ; 卷 38, 編號 1. 頁 201-211.
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title = "Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan",
abstract = "The Pro/Pro polymorphism of p53 codon 72 has been reported to be related to bladder and lung cancer, but its relationship with skin cancer is unclear. We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan. From 1996 to 1999, 93 newly-diagnosed skin cancer patients at the National Cheng-Kung University (NCKU) Hospital and 71 community controls matched on residence were recruited in southwestern Taiwan. The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). A questionnaire was administered to each subject for collection of demographic information, personal habits, disease history, diet information, and other relevant questions. The Pro/Pro (homozygous) genotype was more frequent in skin cancer patients (cases, 20{\%}; controls, 12{\%}; P = 0.37). Subjects with the susceptible genotype Pro/Pro and heterozygous (intermediate) genotype Pro/Arg had 2.18 and 0.99 times risk of skin cancer than the wild type Arg/Arg (95{\%} confidence interval, 0.74-4.38; 95{\%} confidence interval, 0.44-2.21), respectively. Compared with subjects with 18.5 <BMI <23, subjects with BMI > 18.5 had 5.78 times risk of skin cancer (95{\%} confidence interval, 1.06 to 31.36) after adjusting for other risk factors. There was no interaction between BMI and genotype, but the sample size was small. The risk of skin cancer did not significantly vary by tumor cell-type. The risk of skin cancer is increased in individuals with the Pro/Pro genotype. Larger, confirmatory studies are needed to clarify the role of constitutional polymorphisms in p53 and skin cancer risk.",
keywords = "Cumulative arsenic exposure, p53 Codon 72, Skin cancer, Taiwan",
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AU - Chen, Yen Ching

AU - Xu, Lilian

AU - Guo, Yu Liang Leon

AU - Su, Huey Jen Jenny

AU - Hsueh, Yu Mei

AU - Smith, Thomas J.

AU - Ryan, Louise M.

AU - Lee, Meei Shyuan

AU - Chaor, Sheau Chiou

AU - Lee, Julia Yu Yun

AU - Christiani, David C.

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N2 - The Pro/Pro polymorphism of p53 codon 72 has been reported to be related to bladder and lung cancer, but its relationship with skin cancer is unclear. We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan. From 1996 to 1999, 93 newly-diagnosed skin cancer patients at the National Cheng-Kung University (NCKU) Hospital and 71 community controls matched on residence were recruited in southwestern Taiwan. The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). A questionnaire was administered to each subject for collection of demographic information, personal habits, disease history, diet information, and other relevant questions. The Pro/Pro (homozygous) genotype was more frequent in skin cancer patients (cases, 20%; controls, 12%; P = 0.37). Subjects with the susceptible genotype Pro/Pro and heterozygous (intermediate) genotype Pro/Arg had 2.18 and 0.99 times risk of skin cancer than the wild type Arg/Arg (95% confidence interval, 0.74-4.38; 95% confidence interval, 0.44-2.21), respectively. Compared with subjects with 18.5 <BMI <23, subjects with BMI > 18.5 had 5.78 times risk of skin cancer (95% confidence interval, 1.06 to 31.36) after adjusting for other risk factors. There was no interaction between BMI and genotype, but the sample size was small. The risk of skin cancer did not significantly vary by tumor cell-type. The risk of skin cancer is increased in individuals with the Pro/Pro genotype. Larger, confirmatory studies are needed to clarify the role of constitutional polymorphisms in p53 and skin cancer risk.

AB - The Pro/Pro polymorphism of p53 codon 72 has been reported to be related to bladder and lung cancer, but its relationship with skin cancer is unclear. We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan. From 1996 to 1999, 93 newly-diagnosed skin cancer patients at the National Cheng-Kung University (NCKU) Hospital and 71 community controls matched on residence were recruited in southwestern Taiwan. The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). A questionnaire was administered to each subject for collection of demographic information, personal habits, disease history, diet information, and other relevant questions. The Pro/Pro (homozygous) genotype was more frequent in skin cancer patients (cases, 20%; controls, 12%; P = 0.37). Subjects with the susceptible genotype Pro/Pro and heterozygous (intermediate) genotype Pro/Arg had 2.18 and 0.99 times risk of skin cancer than the wild type Arg/Arg (95% confidence interval, 0.74-4.38; 95% confidence interval, 0.44-2.21), respectively. Compared with subjects with 18.5 <BMI <23, subjects with BMI > 18.5 had 5.78 times risk of skin cancer (95% confidence interval, 1.06 to 31.36) after adjusting for other risk factors. There was no interaction between BMI and genotype, but the sample size was small. The risk of skin cancer did not significantly vary by tumor cell-type. The risk of skin cancer is increased in individuals with the Pro/Pro genotype. Larger, confirmatory studies are needed to clarify the role of constitutional polymorphisms in p53 and skin cancer risk.

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