Genetic markers of atopy in infancy: Results from the German Multicenter Allergy Study

R. Nickel, K. Beyer, S. K. Huang, K. C. Barnes, U. Wahn

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6 引文 斯高帕斯(Scopus)

摘要

Genetic studies of atopy-associated traits require unambiguous phenotypes to avoid both type 1 and 2 errors. The German Multicenter Allergy Study has provided a birth cohort with longitudinally well defined and stable phenotypes. We summarize data on candidate gene studies on chromosomes 12q, 5q, and 13q using high total IgE and atopic dermatitis (AD) as the most common atopy associated phenotypes in early childhood. We also present data on a functional RANTES promoter polymorphism that we recently identified. A significantly higher frequency of the mutant allele was seen in individuals of African descent compared to Caucasian subjects. In addition, an association of the polymorphism with AD could be demonstrated in the MAS cohort. Although the statistical approaches are limited, the MAS cohort has provided a valuable population for candidate gene studies in atopy.

原文英語
頁(從 - 到)23-25
頁數3
期刊Clinical and Experimental Allergy, Supplement
29
發行號4
出版狀態已發佈 - 12月 1 1999
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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