摘要

Vascular endothelial growth factor (VEGF) inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs), are important as anticancer treatments through curbing tumour angiogenesis and growth. VEGF inhibitors have significant cardiovascular effects. By blocking VEGF receptors, ligands, or signal pathways, VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity, and activate cardiomyocyte apoptosis. VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia. Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors. This review updates current understandings of VEGF inhibitors on cardiovascular toxicity, explores potential mechanisms, and clarifies whether genetic or ethnic factors contribute to their adverse effects.Key MessagesVEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity and activate cardiomyocyte apoptosis.VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia.Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors.
原文英語
頁(從 - 到)46-56
頁數11
期刊Annals of Medicine
50
發行號1
DOIs
出版狀態已發佈 - 一月 2 2018

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors」主題。共同形成了獨特的指紋。

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