Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells

Yuta Mizuno, Hsi Chang, Katsutsugu Umeda, Akira Niwa, Toru Iwasa, Tomonari Awaya, So Ichiro Fukada, Hiroshi Yamamoto, Shinya Yamanaka, Tatsutoshi Nakahata, Toshio Heike

研究成果: 雜誌貢獻文章同行評審

115 引文 斯高帕斯(Scopus)

摘要

Induced pluripotent stem (iPS) cells, which are a type of pluripotent stem cell generated from reprogrammed somatic cells, are expected to have potential for patient-oriented disease investigation, drug screening, toxicity tests, and transplantation therapies. Here, we demonstrated that murine iPS cells have the potential to develop in vitro into skeletal muscle stem/progenitor cells, which are almost equivalent to murine embryonic stem cells. Cells with strong in vitro myogenic potential effectively were enriched by fluorescence-activated cell sorting using the anti-satellite cell antibody SM/C-2.6. Furthermore, on transplantation into mdx mice, SM/C-2.6+ cells exerted sustained myogenic lineage differentiation in injured muscles, while providing long-lived muscle stem cell support. Our data suggest that iPS cells have the potential to be used in clinical treatment of muscular dystrophies.

原文英語
頁(從 - 到)2245-2253
頁數9
期刊FASEB Journal
24
發行號7
DOIs
出版狀態已發佈 - 七月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology

指紋 深入研究「Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells」主題。共同形成了獨特的指紋。

引用此