@article{4f12ef0ee412420b8896131e06da2101,
title = "Gender difference in clinical and genetic characteristics of Brugada syndrome: SADS-TW BrS registry",
abstract = "Background: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. Aim: To investigate the gender difference of BrS in Han Chinese. Design: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. Methods: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. Results: The percentage of family history of SCD in females was slightly higher (31.3% vs. 15%, P ¼ 0.15). Females exhibited longer QTc (457.8 6 33.0 vs. 429.5 6 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P ¼ 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 6 26.8 vs. 104.8 6 15.3 ms, P ¼ 0.02) and QTc (442.5 6 57.4 vs. 422.9 6 28.8 ms, P ¼ 0.02). Males with syncope exhibited longer PR interval (181.2 6 33.7 vs. 165.7 6 27.1 ms, P ¼ 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 6 9.6 vs. 82.2 6 16.3 bpm, P ¼ 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. Conclusion: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.",
keywords = "Adult, Brugada Syndrome/complications, Death, Sudden, Cardiac/epidemiology, Electrocardiography, Female, Humans, Long QT Syndrome/epidemiology, Male, Middle Aged, Mutation, NAV1.5 Voltage-Gated Sodium Channel/genetics, Registries, Risk Assessment, Sex Distribution, Sex Factors, Syncope/epidemiology, Taiwan/epidemiology",
author = "{SADS-TW BrS Registry} and Chen, {C. Y.J.} and Juang, {J. M.J.} and Lin, {L. Y.} and Liu, {Y. B.} and Ho, {L. T.} and Yu, {C. C.} and Huang, {H. C.} and Lin, {T. T.} and Liao, {M. C.} and Chen, {J. J.} and Hwang, {J. J.} and Chen, {W. J.} and Yeh, {S. F.S.} and Yang, {D. H.} and Chiang, {F. T.} and Lin, {J. L.} and Lai, {L. P.} and M. Horie and Wu, {Mei Hwan} and Wu, {Tsu Juey} and Chen, {Shih Ann} and Wang, {Chun Chieh} and Chang, {Kuan Cheng} and Feng, {An Ning} and Lin, {Yenn Jiang} and Ueng, {Kwo Chang} and Tsao, {Hsuan Ming} and Huang, {Jin Long} and Tsai, {Wen Chin} and Tsai, {Chin Feng} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Chung, {Fa Po} and Chang, {Chien Jung} and Lo, {Huey Ming} and Chiang, {Meng Cheng} and Hsia, {Chih Ping} and Liu, {Jen Fu} and Chiu, {Shuenn Nan} and Lin, {Ming Tai} and Chua, {Su Kiat} and Hsieh, {Yu Cheng} and Li, {Cheng Hung} and Liao, {Ying Chieh} and Lin, {Heng Hsu} and Liu, {Zhi Zhong} and Ye, {Guan Hong} and Chiu, {Wei Ru} and Chang, {Jian Rong}",
note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2019",
month = may,
day = "1",
doi = "10.1093/qjmed/hcz028",
language = "English",
volume = "112",
pages = "343--350",
journal = "QJM - Monthly Journal of the Association of Physicians",
issn = "1460-2725",
publisher = "Oxford University Press",
number = "5",
}