Background: Studies have reported that women with ST elevationmyocardial infarction (STEMI) have worse shortand long-term outcomes than men. It has not yet been confirmed whether these differences reflect differences in age between men and women. Methods: We retrospectively enrolled 1035 consecutive STEMI patients treated with primary percutaneous coronary intervention (PCI). Baseline clinical characteristics, coronary anatomy, and outcome were compared between young (<65 years old) and older patients (≥ 65 years old) of both sexes. Results: Younger women presented with a lower incidence of typical angina (83% vs. 93%, p = 0.03), single-vessel disease (21% vs. 35%, p = 0.03), and total occlusion of infarct-related artery (65% vs. 83%, p = 0.001) than younger men, with no gender difference noted in the older group. Younger women in the study had a higher incidence of reinfarction, heart failure requiring admission, or mortality (23% vs. 6%, p <0.001) during follow-up, compared with younger men, with no gender difference in the older group. Using the Kaplan-Meier analysis, younger women had lower rates of event-free survival (p <0.001 by log-rank test) than younger men, with no gender difference in the older group. In multivariate analysis, age could predict long-term outcome in men (Hazard ratio 4.43, 95% confidence interval: 2.89-6.78, p <0.001) but not in women. Conclusions: In STEMI patients receiving primary PCI, sex-related long-term outcome differences were agedependent, with younger women likely to have a worse long-term outcome when compared with younger men.
|頁（從 - 到）||274-283|
|期刊||Acta Cardiologica Sinica|
|出版狀態||已發佈 - 七月 1 2014|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Chua, S. K., Shyu, K. G., Hung, H. F., Cheng, J. J., Lo, H. M., Liu, S. C., Chen, L. C., Chiu, N. Z., Chang, C. M., Lin, S. C., Liou, J. Y., & Lee, S. H. (2014). Gender and age differences in short- and long-term outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction. Acta Cardiologica Sinica, 30(4), 274-283.