Gastroprotective effect of Lycium barbarum polysaccharides and C-phyocyanin in rats with ethanol-induced gastric ulcer

Yu Zhi Lian, I. Hsuan Lin, Yu Chen Yang, Jane C.J. Chao

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

This study investigated the gastroprotective effect of Lycium barbarum polysaccharides (LBP) and C-phycoyanin (C-PC) in rats with ethanol-induced gastric ulcer. Rats were divided into 5 groups: normal, ulcer, ulcer treated with 100 mg/kg bw LBP, ulcer treated with 50 mg/kg bw C-PC, and ulcer treated with 50 mg/kg bw LBP and 25 mg/kg bw C-PC. Pretreatment with LBP and/or C-PC was given a week before ulcer induction. Ulcer induction was produced by 50% ethanol administration orally every other day for 4 weeks. After 5-week treatment, the histopathological observation showed that LBP or C-PC attenuated the severity of gastric mucosal damage. LBP decreased serum malondialdehyde (MDA) levels and gastric interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) levels, and myeloperoxidase (MPO) activity. C-PC decreased serum MDA levels and gastric tumor necrosis factor-α (TNF-α), IL-1β, IL-6, ICAM-1 levels, and MPO activity. Combined LBP and C-PC decreased serum MDA levels and gastric TNF-α, IL-1β, IL-6, and ICAM-1 levels. LBP and/or C-PC increased gastric heat shock protein 70 and non-protein sulfhydryl compounds. Rats with ulcer and treatment had enriched with the family Bacillaceae. Therefore, pretreatment with LBP and/or C-PC attenuated ethanol-induced gastric ulcer in rats via suppressing oxidation and inflammation and increasing gastroprotection.
原文英語
頁(從 - 到)1519-1528
頁數10
期刊International Journal of Biological Macromolecules
165
DOIs
出版狀態已發佈 - 12月 15 2020

ASJC Scopus subject areas

  • 結構生物學
  • 生物化學
  • 分子生物學
  • 經濟學與計量經濟學
  • 能源(全部)

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