Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis

Chun Pin Chiang, Julia Yu-Fong Chang, Yi Ping Wang, Yu Hsueh Wu, Yang Che Wu, Andy Sun

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Results: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.
原文英語
頁(從 - 到)973-978
頁數6
期刊Journal of the Formosan Medical Association
118
發行號6
DOIs
出版狀態已發佈 - 六月 1 2019
對外發佈Yes

指紋

Glossitis
Gastric Parietal Cells
Autoantibodies
Thyroid Gland
Thyroglobulin
Antibodies
Serum
Healthy Volunteers
Thyrotropin
thyroid microsomal antibodies

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. / Chiang, Chun Pin; Yu-Fong Chang, Julia; Wang, Yi Ping; Wu, Yu Hsueh; Wu, Yang Che; Sun, Andy.

於: Journal of the Formosan Medical Association, 卷 118, 編號 6, 01.06.2019, p. 973-978.

研究成果: 雜誌貢獻文章

Chiang, Chun Pin ; Yu-Fong Chang, Julia ; Wang, Yi Ping ; Wu, Yu Hsueh ; Wu, Yang Che ; Sun, Andy. / Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. 於: Journal of the Formosan Medical Association. 2019 ; 卷 118, 編號 6. 頁 973-978.
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abstract = "Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Results: We found that 26.7{\%}, 28.4{\%}, and 29.8{\%} of 1064 AG patients and 2.3{\%}, 2.1{\%}, and 2.6{\%} of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3{\%}), 181 (17.0{\%}), and 340 (32.0{\%}) AG patients and 3 (0.6{\%}), 10 (1.9{\%}), and 8 (1.5{\%}) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6{\%}, 8.0{\%}, and 13.4{\%} of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 55.3{\%} of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.",
keywords = "Atrophic glossitis, Gastric parietal cell antibody, Thyroglobulin antibody, Thyroid microsomal antibody",
author = "Chiang, {Chun Pin} and {Yu-Fong Chang}, Julia and Wang, {Yi Ping} and Wu, {Yu Hsueh} and Wu, {Yang Che} and Andy Sun",
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T1 - Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis

AU - Chiang, Chun Pin

AU - Yu-Fong Chang, Julia

AU - Wang, Yi Ping

AU - Wu, Yu Hsueh

AU - Wu, Yang Che

AU - Sun, Andy

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Results: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.

AB - Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Results: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.

KW - Atrophic glossitis

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KW - Thyroglobulin antibody

KW - Thyroid microsomal antibody

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