Gastric parietal cell and thyroid autoantibodies in oral precancer patients

Yu Hsueh Wu, Yang Che Wu, Shih Jung Cheng, Ying Shiung Kuo, Andy Sun, Hsin Ming Chen

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. Results: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008). Conclusion: Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism.
原文英語
期刊Journal of the Formosan Medical Association
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Gastric Parietal Cells
Autoantibodies
Thyroid Gland
Thyroglobulin
Antibodies
Serum
Thyrotropin
Tobacco Products
thyroid microsomal antibodies
Healthy Volunteers
Mouth Diseases
Oral Leukoplakia

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Gastric parietal cell and thyroid autoantibodies in oral precancer patients. / Wu, Yu Hsueh; Wu, Yang Che; Cheng, Shih Jung; Kuo, Ying Shiung; Sun, Andy; Chen, Hsin Ming.

於: Journal of the Formosan Medical Association, 01.01.2019.

研究成果: 雜誌貢獻文章

Wu, Yu Hsueh ; Wu, Yang Che ; Cheng, Shih Jung ; Kuo, Ying Shiung ; Sun, Andy ; Chen, Hsin Ming. / Gastric parietal cell and thyroid autoantibodies in oral precancer patients. 於: Journal of the Formosan Medical Association. 2019.
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title = "Gastric parietal cell and thyroid autoantibodies in oral precancer patients",
abstract = "Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. Results: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7{\%} vs. 2.3{\%}, P = 0.012, statistically significant), TGA (4.6{\%} vs. 2.3{\%}, P = 0.498), and TMA (8.4{\%} vs. 2.3{\%}, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8{\%}), 6 (4.6{\%}), and 16 (12.2{\%}) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80{\%}, 10{\%}, and 10{\%} of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008). Conclusion: Approximately 17.6{\%} of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20{\%} of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism.",
keywords = "Gastric parietal cell antibody, Oral leukoplakia, Oral precancer, Thyroglobulin antibody, Thyroid microsomal antibody",
author = "Wu, {Yu Hsueh} and Wu, {Yang Che} and Cheng, {Shih Jung} and Kuo, {Ying Shiung} and Andy Sun and Chen, {Hsin Ming}",
year = "2019",
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journal = "Journal of the Formosan Medical Association",
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T1 - Gastric parietal cell and thyroid autoantibodies in oral precancer patients

AU - Wu, Yu Hsueh

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Kuo, Ying Shiung

AU - Sun, Andy

AU - Chen, Hsin Ming

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. Results: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008). Conclusion: Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism.

AB - Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. Results: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008). Conclusion: Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism.

KW - Gastric parietal cell antibody

KW - Oral leukoplakia

KW - Oral precancer

KW - Thyroglobulin antibody

KW - Thyroid microsomal antibody

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