Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis

Yu Hsueh Wu, Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Hsin Ming Chen, Andy Sun

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG + RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.
原文英語
頁(從 - 到)691-696
頁數6
期刊Journal of the Formosan Medical Association
117
發行號8
DOIs
出版狀態已發佈 - 八月 1 2018
對外發佈Yes

指紋

Glossitis
Gastric Parietal Cells
Behcet Syndrome
Autoantibodies
Thyroid Gland
Thyroglobulin
Antibodies
Serum
Healthy Volunteers
Sutton disease 2

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. / Wu, Yu Hsueh; Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Chen, Hsin Ming; Sun, Andy.

於: Journal of the Formosan Medical Association, 卷 117, 編號 8, 01.08.2018, p. 691-696.

研究成果: 雜誌貢獻文章

Wu, Yu Hsueh ; Chang, Julia Yu Fong ; Wang, Yi Ping ; Wu, Yang Che ; Chen, Hsin Ming ; Sun, Andy. / Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. 於: Journal of the Formosan Medical Association. 2018 ; 卷 117, 編號 8. 頁 691-696.
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title = "Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis",
abstract = "Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0{\%}, 30.0{\%}, and 26.7{\%} of 30 AG + RAS/BD patients, 9.1{\%}, 12.1{\%}, and 15.2{\%} of 33 AG־RAS/BD patients, and 1.6{\%}, 2.4{\%}, and 2.4{\%} of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.",
keywords = "Atrophic glossitis, Behcet's disease, Gastric parietal cell antibody, Recurrent aphthous stomatitis, Thyroglobulin antibody, Thyroid microsomal antibody",
author = "Wu, {Yu Hsueh} and Chang, {Julia Yu Fong} and Wang, {Yi Ping} and Wu, {Yang Che} and Chen, {Hsin Ming} and Andy Sun",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.jfma.2018.03.015",
language = "English",
volume = "117",
pages = "691--696",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "8",

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TY - JOUR

T1 - Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis

AU - Wu, Yu Hsueh

AU - Chang, Julia Yu Fong

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Chen, Hsin Ming

AU - Sun, Andy

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG + RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.

AB - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG + RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.

KW - Atrophic glossitis

KW - Behcet's disease

KW - Gastric parietal cell antibody

KW - Recurrent aphthous stomatitis

KW - Thyroglobulin antibody

KW - Thyroid microsomal antibody

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