Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo

Shih Chung Hsu, Chien Chih Ou, Tzu Chao Chuang, Jhy Wei Li, Yi Jen Lee, Vinchi Wang, Jah Yao Liu, Chin Shiang Chen, Song Chow Lin, Ming Ching Kao

研究成果: 雜誌貢獻文章

39 引文 斯高帕斯(Scopus)

摘要

We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.
原文英語
頁(從 - 到)108-116
頁數9
期刊Cancer Letters
281
發行號1
DOIs
出版狀態已發佈 - 八月 18 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Hsu, S. C., Ou, C. C., Chuang, T. C., Li, J. W., Lee, Y. J., Wang, V., Liu, J. Y., Chen, C. S., Lin, S. C., & Kao, M. C. (2009). Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo. Cancer Letters, 281(1), 108-116. https://doi.org/10.1016/j.canlet.2009.02.032