Ganoderma Lucidum Reduces Inflammation- Induced Bone Loss: A Pilot Study in Rats

Pei-Wei Weng, Po-Hsien Huang, Ming-Chieh Hsieh, Wan-Chien Cheng, Ching-Liang Chu, Dz-Chi Chen, Cheng-En Sung, Ren-Yeong Huang

研究成果: 雜誌貢獻文章

摘要

Background: Periodontal diseases are characterized by destruction of the tooth-supporting structure and may be a hazard to general health. Ganoderma lucidum (GL) has had a variety of pharmacological activities on joint-derived tissues/cells for decades. However, the therapeutic potential of GL on periodontal destruction has not been investigated. In the present study, we investigated the effects of GL in a rat model of periodontal disease induced by ligature placement.
Materials and methods: Male Sprague Dawley rats were divided into three groups: 1) animals without ligature placement receiving empty vehicle (control); 2) animals with ligature receiving empty vehicle; 3) animals with ligature receiving GL (10 mg/kg/day). The animals were sacrificed on day 10, and tissue samples were prepared for further analysis.
Results: The results demonstrated that the administration of GL ameliorated periodontal and bone destruction. Histomorphological analyses revealed that GL treatment decreased infiltration of polymorphonuclear cells in periodontal tissues.
Conclusion: These findings suggest that GL could constitute a promising therapeutic drug to treat periodontal disease.
原文英語
期刊Journal of Periodontics and Implant Dentistry
1
發行號1
出版狀態已發佈 - 2018

指紋

Reishi
Osteitis
Ligation
Periodontal Diseases
Periodontium
Sprague Dawley Rats
Joints
Pharmacology
Bone and Bones
Health
Therapeutics

引用此文

Weng, P-W., Huang, P-H., Hsieh, M-C., Cheng, W-C., Chu, C-L., Chen, D-C., ... Huang, R-Y. (2018). Ganoderma Lucidum Reduces Inflammation- Induced Bone Loss: A Pilot Study in Rats. Journal of Periodontics and Implant Dentistry, 1(1).

Ganoderma Lucidum Reduces Inflammation- Induced Bone Loss : A Pilot Study in Rats. / Weng, Pei-Wei; Huang, Po-Hsien ; Hsieh, Ming-Chieh ; Cheng, Wan-Chien ; Chu, Ching-Liang ; Chen, Dz-Chi ; Sung, Cheng-En ; Huang, Ren-Yeong .

於: Journal of Periodontics and Implant Dentistry, 卷 1, 編號 1, 2018.

研究成果: 雜誌貢獻文章

Weng, P-W, Huang, P-H, Hsieh, M-C, Cheng, W-C, Chu, C-L, Chen, D-C, Sung, C-E & Huang, R-Y 2018, 'Ganoderma Lucidum Reduces Inflammation- Induced Bone Loss: A Pilot Study in Rats', Journal of Periodontics and Implant Dentistry, 卷 1, 編號 1.
Weng, Pei-Wei ; Huang, Po-Hsien ; Hsieh, Ming-Chieh ; Cheng, Wan-Chien ; Chu, Ching-Liang ; Chen, Dz-Chi ; Sung, Cheng-En ; Huang, Ren-Yeong . / Ganoderma Lucidum Reduces Inflammation- Induced Bone Loss : A Pilot Study in Rats. 於: Journal of Periodontics and Implant Dentistry. 2018 ; 卷 1, 編號 1.
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T2 - A Pilot Study in Rats

AU - Weng, Pei-Wei

AU - Huang, Po-Hsien

AU - Hsieh, Ming-Chieh

AU - Cheng, Wan-Chien

AU - Chu, Ching-Liang

AU - Chen, Dz-Chi

AU - Sung, Cheng-En

AU - Huang, Ren-Yeong

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AB - Background: Periodontal diseases are characterized by destruction of the tooth-supporting structure and may be a hazard to general health. Ganoderma lucidum (GL) has had a variety of pharmacological activities on joint-derived tissues/cells for decades. However, the therapeutic potential of GL on periodontal destruction has not been investigated. In the present study, we investigated the effects of GL in a rat model of periodontal disease induced by ligature placement.Materials and methods: Male Sprague Dawley rats were divided into three groups: 1) animals without ligature placement receiving empty vehicle (control); 2) animals with ligature receiving empty vehicle; 3) animals with ligature receiving GL (10 mg/kg/day). The animals were sacrificed on day 10, and tissue samples were prepared for further analysis.Results: The results demonstrated that the administration of GL ameliorated periodontal and bone destruction. Histomorphological analyses revealed that GL treatment decreased infiltration of polymorphonuclear cells in periodontal tissues.Conclusion: These findings suggest that GL could constitute a promising therapeutic drug to treat periodontal disease.

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