Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes

Hsing Hsien Cheng, Chien Y. Ma, Tsui W. Chou, Ya Y. Chen, Ming Hoang Lai

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
原文英語
頁(從 - 到)45-53
頁數9
期刊International Journal for Vitamin and Nutrition Research
80
發行號1
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • 醫藥(雜項)
  • 內分泌學、糖尿病和代謝
  • 營養與營養學

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