Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes

Yi Chieh Hung, Cheng Chia Lee, Wan Yuo Guo, Cheng Ying Shiau, Yue Cune Chang, David Hung Chi Pan, Jason P. Sheehan, Wen Yuh Chung

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Purpose: To evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of cavernous sinus (CS) meningiomas. Methods: We retrospectively reviewed the clinical and radiological outcomes of 95 patients with CS meningiomas at Taipei Veterans General Hospital between 1993 and 2011. The study cohort comprised 27 men and 68 women with a median age of 50 years (range 29–79 years). The median pre-GKRS tumor volume was 6.6 ml (range 0.9–35.7 ml). The median margin dose was 12 Gy (range 11–21 Gy). The clinical factors related to favorable outcomes were assessed. Results: The median follow-up period was 59 (range 12–209) months. At the final follow-up, the tumor volume regressed in 70 patients (74%) and progressed in eight (8%). Kaplan–Meier analysis revealed that the progression-free survival rates at 5 and 10 years were 92.7% and 81.2%, respectively. Three patients (3.2%) experienced exacerbated cranial nerve dysfunction following radiosurgery. Confined tumors were found to be an independent prognostic factor for tumor control and shorter times to regression in the multivariable analyses. No risk factor for tumor progression was identified in either the univariate or multivariate analyses. Conclusions: GKRS provides good long-term tumor control and is associated with low cranial nerve–related morbidity development rates in patients with small- to medium-sized CS meningiomas. Confined tumor could be an independent prognostic factor for tumor control and shorter times to regression in multivariate analysis. Life-long follow-up is mandatory in such settings, even for outpatients with shrunken or stabilized tumors.

原文英語
頁(從 - 到)261-270
頁數10
期刊Journal of Neuro-Oncology
143
發行號2
DOIs
出版狀態已發佈 - 6月 1 2019

ASJC Scopus subject areas

  • 腫瘤科
  • 神經內科
  • 神經病學(臨床)
  • 癌症研究

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