Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin, Yann Hung, Jen Kuan Su, Rain Lee, Chen Chang, Meng Liang Lin, Chung Yuan Mou

研究成果: 雜誌貢獻文章同行評審

128 引文 斯高帕斯(Scopus)

摘要

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

原文英語
頁(從 - 到)15608-15611
頁數4
期刊Journal of Physical Chemistry B
108
發行號40
DOIs
出版狀態已發佈 - 10月 7 2004
對外發佈

ASJC Scopus subject areas

  • 物理與理論化學
  • 表面、塗料和薄膜
  • 材料化學

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