GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: A combined fMRI/MEG study with placebo and lorazepam

Georg Northoff, Thomas Witzel, Andre Richter, Matthias Gessner, Florian Schlagenhauf, Jürgen Fell, Frank Baumgart, Thomas Kaulisch, Claus Tempelmann, Alexander Heinzel, Rolf Kötter, Tilman Hagner, Bela Bargel, Hermann Hinrichs, Bernhard Bogerts, Henning Scheich, Hans Jochen Heinze

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41 引文 斯高帕斯(Scopus)

摘要

Various prefrontal cortical regions have been shown to be activated during emotional stimulation, whereas neurochemical mechanisms underlying emotional processing in the prefrontal cortex remain unclear. We therefore investigated the influence of the GABA-A potentiator lorazepam on prefrontal cortical emotional-motor spatio-temporal activation pattern in a combined functional magnetic resonance imaging/magnetoencephalography study. Lorazepam led to the reversal in orbito-frontal activation pattern, a shift of the early magnetic field dipole from the orbito-frontal to medial prefrontal cortex, and alterations in premotor/motor cortical function during negative and positive emotional stimulation. It is concluded that negative emotional processing in the orbito-frontal cortex may be modulated either directly or indirectly by GABA-A receptors. Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional.
原文英語
頁(從 - 到)348-370
頁數23
期刊Journal of Cognitive Neuroscience
14
發行號3
DOIs
出版狀態已發佈 - 4月 1 2002
對外發佈

ASJC Scopus subject areas

  • 行為神經科學
  • 實驗與認知心理學
  • 認知神經科學

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