GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

Georg Northoff, Martin Walter, Rolf F. Schulte, Johannes Beck, Ulrike Dydak, Anke Henning, Heinz Boeker, Simone Grimm, Peter Boesiger

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281 引文 斯高帕斯(Scopus)

摘要

The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.
原文英語
頁(從 - 到)1515-1517
頁數3
期刊Nature Reviews Neuroscience
10
發行號12
DOIs
出版狀態已發佈 - 十二月 2007
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)

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