G801A Polymorphism of human stromal cell-derived factor 1 gene raises no susceptibility to neoplastic lesions of uterine cervix

Yi Torng Tee, Shun Fa Yang, Po Hui Wang, Hsiu Ting Tsai, Long Yau Lin, Shu Kuei Lee, Chiung Ling Liao, Jinghau Tsai Chang, Yang Tse Shih

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Objective: This study aimed to investigate the association of stromal cellYderived factor 1 (SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in Mid-Taiwan women. Materials and Methods: Four hundred ninety-eight blood samples were collected from 161 patients with neoplasia of uterine cervix, including 76 cancer patients, 61 patients with high-grade dysplasia, and 24 with low-grade dysplasia, and 337 healthy controls who lived in Mid-Taiwan. Polymorphism of the SDF-1 gene was examined using polymerase chain reactionYrestriction fragment length polymorphism. Results: For SDF-1 gene polymorphisms, the wild-type homozygous alleles (G/G) yielded 100- and 193-bp products, the heterozygous alleles (G/A) yielded 100-, 193- and 293-bp products, whereas the mutated-type homozygous alleles (A/A) yielded a 293-bp product. We found no significant difference in genotypes or alleles distribution of SDF-1 polymorphisms between patients with cervical neoplasia and healthy women (P = 0.530). Compared with the homozygous GG subgroup, GA and AA subgroups do not increase the risk of cervical neoplasia. Conclusions: Although the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia.

原文英語
頁(從 - 到)1297-1302
頁數6
期刊International Journal of Gynecological Cancer
22
發行號8
DOIs
出版狀態已發佈 - 2012
對外發佈Yes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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