G-Protein Coupled Estrogen Receptor in Breast Cancer

Li Han Hsu, Nei Min Chu, Yung Feng Lin, Shu Huei Kao

研究成果: 雜誌貢獻回顧型文獻

6 引文 (Scopus)

摘要

The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.
原文英語
期刊International Journal of Molecular Sciences
20
發行號2
DOIs
出版狀態已發佈 - 一月 14 2019

指紋

estrogens
G-Protein-Coupled Receptors
GTP-Binding Proteins
breast
Estrogen Receptors
cancer
Breast Neoplasms
proteins
Proteins
Triple Negative Breast Neoplasms
Estrogens
Tamoxifen
Disease Management
Epidermal Growth Factor Receptor
Tissue

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

引用此文

G-Protein Coupled Estrogen Receptor in Breast Cancer. / Hsu, Li Han; Chu, Nei Min; Lin, Yung Feng; Kao, Shu Huei.

於: International Journal of Molecular Sciences, 卷 20, 編號 2, 14.01.2019.

研究成果: 雜誌貢獻回顧型文獻

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abstract = "The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50{\%} to 60{\%} of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15{\%} to 20{\%} of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.",
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