Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor

Bo Hon Chou, Li Ming Yang, Shwu Fen Chang, Feng Lin Hsu, Chia Hsin Lo, Wen Kuang Lin, Li Hsuan Wang, Pan Chun Liu, Shwu Jiuan Lin

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4α-carboxy-13α-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucor recurvatus MR 36, Aspergillus niger BCRC 31130, and Absidia pseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp. niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques (1H, 13C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone.

原文英語
頁(從 - 到)759-764
頁數6
期刊Phytochemistry
70
發行號6
DOIs
出版狀態已發佈 - 四月 2009

ASJC Scopus subject areas

  • 植物科學
  • 生物化學
  • 分子生物學
  • 園藝科學

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