摘要
A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4α-carboxy-13α-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucor recurvatus MR 36, Aspergillus niger BCRC 31130, and Absidia pseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp. niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques (1H, 13C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone.
原文 | 英語 |
---|---|
頁(從 - 到) | 759-764 |
頁數 | 6 |
期刊 | Phytochemistry |
卷 | 70 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 四月 2009 |
ASJC Scopus subject areas
- Plant Science
- Biochemistry
- Molecular Biology
- Horticulture
指紋 深入研究「Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor」主題。共同形成了獨特的指紋。
資料集
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CCDC 706277: Experimental Crystal Structure Determination
Chou, B. (Contributor), Yang, L. (Contributor), Chang, S. (Contributor), Hsu, F. (Contributor), Lo, C. (Contributor), Lin, W. (Contributor), Wang, L. (Contributor), Liu, P. (Contributor) & Lin, S. (Contributor), Unknown Publisher, 一月 1 2010
DOI: 10.5517/ccrpy4h, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccrpy4h&sid=DataCite
資料集: Dataset
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CCDC 706276: Experimental Crystal Structure Determination
Chou, B. (Contributor), Yang, L. (Contributor), Chang, S. (Contributor), Hsu, F. (Contributor), Lo, C. (Contributor), Lin, W. (Contributor), Wang, L. (Contributor), Liu, P. (Contributor) & Lin, S. (Contributor), Unknown Publisher, 一月 1 2010
DOI: 10.5517/ccrpy3g, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccrpy3g&sid=DataCite
資料集: Dataset