Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor

Bo Hon Chou, Li Ming Yang, Shwu Fen Chang, Feng Lin Hsu, Chia Hsin Lo, Wen Kuang Lin, Li Hsuan Wang, Pan Chun Liu, Shwu Jiuan Lin

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4α-carboxy-13α-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucor recurvatus MR 36, Aspergillus niger BCRC 31130, and Absidia pseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp. niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques (1H, 13C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone.

原文英語
頁(從 - 到)759-764
頁數6
期刊Phytochemistry
70
發行號6
DOIs
出版狀態已發佈 - 四月 2009

指紋

Aspergillus niger
Diterpenes
Macrophages
Aspergillus
Transcription Factor AP-1
Lactones
lactones
Dexamethasone
Lipopolysaccharides
Transcription Factors
Absidia
transcription factors
Chemical activation
Nuclear magnetic resonance
Mucor
X rays
Acids
dexamethasone
diterpenoids
lipopolysaccharides

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

引用此文

Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor. / Chou, Bo Hon; Yang, Li Ming; Chang, Shwu Fen; Hsu, Feng Lin; Lo, Chia Hsin; Lin, Wen Kuang; Wang, Li Hsuan; Liu, Pan Chun; Lin, Shwu Jiuan.

於: Phytochemistry, 卷 70, 編號 6, 04.2009, p. 759-764.

研究成果: 雜誌貢獻文章

Chou, Bo Hon ; Yang, Li Ming ; Chang, Shwu Fen ; Hsu, Feng Lin ; Lo, Chia Hsin ; Lin, Wen Kuang ; Wang, Li Hsuan ; Liu, Pan Chun ; Lin, Shwu Jiuan. / Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor. 於: Phytochemistry. 2009 ; 卷 70, 編號 6. 頁 759-764.
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